Abstract Recurrent event data usually occur in long-term studies which concern
recurrence rates of the disease. In studies of medical sciences, patients who have infected
with the disease, like cancer, were conventionally regarded as impossible to be cured. However,
with the development of medical sciences, recently those patients were found to be possibly
recovered from the disease. The recurrence rate of the events, which is of primary interest,
may be affected by the cure rate that may exist. Therefore, we proposed semiparametric
statistical analysis for recurrent event data with subjects possibly being cured. In our
approach, we present a proportional rate model for recurrence rate with the cure rate adjusted
through a Logistic regression model, and develop some estimating equations for estimation of
the regression parameters, with their large sample properties, including consistency and
asymptotic normality established. Numerical studies under different settings were conducted
for assessing the proposed methodology and the results suggest that they work well for
practical situations. The approach is applied to a bladder cancer dataset which motivated our
study.
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