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Screening Early Based on Changepoint Test for Ovarian Cancer
Liu Mei, Zhang Xiaoran, Fang Xiangzhong
School of Mathematics and Computer, Ningxia Teachers University; School of Sciences, Yanshan University; School of Mathematics Sciences, Peking University
In the paper a change-point model of
ca125 longitudinal data for single subject was established. The
formulae of the maximum likelihood estimate for model parameters
were presented. A likelihood ratio test statistic for early
screening of ovarian cancer was proposed. The critical values of
likelihood ratio test statistic was calculated by Monte Carlo method
in some cases. At last the power and robustness of the likelihood
ratio test were discussed.