癌症统计学治愈的统计学检验
A STATISTICAL TEST FOR THE ACTUARIAL SURVIVAL IN CANCER
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摘要: 统计学治愈是癌症治疗的宏观目标,尚无满意评价方法。循非参数途径,本文提出样本与总体队列半数生存期差别的显著性检验:反射统计量和检基统计量,用于这种评价。截尾问题的处理是以指数内插方程利用Kaplan-Meier或Berkson-Gage估计值,因此,该统计量适于各种生存资料:截尾的,非截尾的,分组的,不分组的。本文为适应截尾而作的所有扩展均具有还原性,无截尾时,该统计量还原为经典中位数检验。附有工作实例描述评价过程。Abstract: The Actuarial survival is a macroscopic goal in cancer treatment, for which there has been no satisfac-toryevaluation procedure. A nonparametrio significance test is proposed for the differenco of cohort half-lives between sample and population. It is expressed as the ref-lected statistic the test-based statistio and used for evaluating the actuarial survival. Kaplan-Meier or Berkson-Gage estimate is utilized via the exponential interpolation equation for adjusting the effect of censorship so that it is suitable for various kinds of data: censoredor uncensored, grouped or ungrouped. It reduces to the classical median test when there is no censoring as all generalizations for adjusting the effect of censorship have the reducibility. A worked out example illustrates the methodology.