Abstract: Considering a parameter estimation and variable selection problem in logistic regression, we propose Smooth LASSO and Spline LASSO. When the variables is continuous, using Smooth LASSO can select local constant coefficient in each group. However, in some case, the coefficient might be different and change smoothly. Using Spline Lasso to estimate parameter is more appropriate. In this article, we prove the reliability of the model by theory. Finally using coordinate descent algorithm to solve the model. Simulations show that the model works very effectively both in feature selection and prediction accuracy.